Derivation Web

claim_e6a9708f31fe435c

# Source literature boundary memo

## Research question

Across retrieved fact-level receipts for mtor, which endpoints show directionally favorable versus null/non-convergent signals, and what matched PICO remains untested?

## Selection criteria

The source-literature fallback selected mtor because the domain snapshot exposed enough fact-backed, topic-overlapping papers. The fallback requires at…

source_ccd949c5d6ae4860

# Source literature boundary memo

## Research question

Across retrieved fact-level receipts for mtor, which endpoints show directionally favorable versus null/non-convergent signals, and what matched PICO remains untested?

## Selection criteria

The source-literature fallback selected mtor because the domain snapshot exposed enough fact-backed, topic-overlapping papers. The fallback requires at…

source_4ddade3ca4184ba5

{"publication_id": "4e5f3bb0-f06e-45a7-a244-efc65bf18284", "traces": [{"candidate_sources": [{"doi": "10.1093/ndt/gfad258", "study": "International consensus on post-transplantation diabetes mellitus", "url": "https://doi.org/10.1093/ndt/gfad258"}, {"doi": "10.1126/scitranslmed.3009892", "study": "mTOR inhibition improves immune function in the elderly", "url": "https://doi.org/10.1126/scitranslme…

source_faa419ffaa8e4c8a

{"content_hash": null, "edges": [{"from": "4e5f3bb0-f06e-45a7-a244-efc65bf18284", "to": "claim_1", "type": "contains_claim"}, {"from": "4e5f3bb0-f06e-45a7-a244-efc65bf18284", "to": "claim_2", "type": "contains_claim"}, {"from": "4e5f3bb0-f06e-45a7-a244-efc65bf18284", "to": "claim_3", "type": "contains_claim"}, {"from": "4e5f3bb0-f06e-45a7-a244-efc65bf18284", "to": "claim_4", "type": "contains_clai…

source_f1797f0fe2044ff8

{"contradictions": ["This receipt-backed scoping note has one bounded signal: mtor shows context-dependent, not convergent, associations across this 5-source primary/review bundle (2010-2024). Grouped by direction, directionally favorable: RAD001 improved influenza vaccine response by ~20% in the elderly; Metformin decreased tumor burden by 72%, which correlated with decreased cellular proliferati…

source_e9db364c80ef46eb

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
International consensus on post-transplantation diabetes mellitus,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
mTOR inhibition improves immune function in the elderly,not extracted,not extracted,not extracted,not extracted,not extracted,not…

source_72ce6c7c3fe942f9

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "4e5f3bb0-f06e-45a7-a244-efc65bf18284", "sources": [{"directness": "primary", "doi": "10.1093/ndt/gfad258", "risk_of_bias": "not appraised in public sidecar", "study": "International consensus on post-transplantation diabetes mellitus"}, …

source_f6c780638f964e26

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}