Derivation Web

claim_f2db5432831b4b16

# Research Synthesis: Senescence Cancer Effects — full paper

## Abstract

This paper synthesizes evidence on senescence cancer effects across 13 accepted source papers and 220 high-confidence extracted claims.

The evidence profile contains no sources classified primarily as direct clinical evidence, 13 adjacent clinical sources, and no sources classified primarily as mechanistic or model-system …

source_30b280d92b4e4f9d

# Research Synthesis: Senescence Cancer Effects — full paper

## Abstract

This paper synthesizes evidence on senescence cancer effects across 13 accepted source papers and 220 high-confidence extracted claims.

The evidence profile contains no sources classified primarily as direct clinical evidence, 13 adjacent clinical sources, and no sources classified primarily as mechanistic or model-system …

source_592c1585dc744281

{"publication_id": "ad6bd204-1859-4516-b412-8f3a7f40f350", "traces": [{"candidate_sources": [{"doi": "10.1186/s12979-024-00487-4", "study": "CD57 + EMRA CD8 + T cells in cancer patients over 70: associations with prior chemotherapy and response to anti-PD-1/PD-L1 therapy", "url": "https://doi.org/10.1186/s12979-024-00487-4"}, {"doi": "10.1007/s11357-022-00685-2", "study": "Associations between bio…

source_c1b8179bb08d4b60

{"content_hash": "sha256:7ae5a315ae658da48e93a33c1241916c042f53feec57cfb3425080c47968322b", "edges": [{"from": "ad6bd204-1859-4516-b412-8f3a7f40f350", "to": "claim_1", "type": "contains_claim"}, {"from": "ad6bd204-1859-4516-b412-8f3a7f40f350", "to": "claim_2", "type": "contains_claim"}, {"from": "ad6bd204-1859-4516-b412-8f3a7f40f350", "to": "claim_3", "type": "contains_claim"}, {"from": "ad6bd204-…

source_0c8e9b1f8e7f4970

{"contradictions": ["The conclusion is that senescence cancer effects remains a bounded geroscience case: the retained clinical and adjacent evidence profile defines the scope for targeted testing, while mixed and null findings limit any unqualified anti-aging claim.", "The curated corpus lacks randomized controlled trials (RCTs) directly testing senescence-targeting interventions against cancer o…

source_35d4d2bb123e49d4

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
CD57 + EMRA CD8 + T cells in cancer patients over 70: associations with prior chemotherapy and response to anti-PD-1/PD-L1 therapy,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Associations between biomarkers of cellular senescence and physi…

source_30d389b7065a453a

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "ad6bd204-1859-4516-b412-8f3a7f40f350", "sources": [{"directness": "primary", "doi": "10.1186/s12979-024-00487-4", "risk_of_bias": "not appraised in public sidecar", "study": "CD57 + EMRA CD8 + T cells in cancer patients over 70: associat…

source_35419c8a9bb34f3a

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}