Derivation Web

claim_1bb241cdd38b4a01

# Hypothesis-Generating Brief: Therapeutic plasma exchange — full paper

## Abstract

This paper synthesizes evidence on Therapeutic plasma exchange across 28 accepted source papers and 1449 high-confidence extracted claims.

The evidence profile contains 4 direct clinical sources, 24 adjacent clinical sources, and no sources classified primarily as mechanistic or model-system evidence, with a hig…

source_2f279b340cdd45ff

# Hypothesis-Generating Brief: Therapeutic plasma exchange — full paper

## Abstract

This paper synthesizes evidence on Therapeutic plasma exchange across 28 accepted source papers and 1449 high-confidence extracted claims.

The evidence profile contains 4 direct clinical sources, 24 adjacent clinical sources, and no sources classified primarily as mechanistic or model-system evidence, with a hig…

source_2f324b7e482a4622

{"publication_id": "21652f17-8a22-4863-aa37-ec5f4e1a7b90", "traces": [{"candidate_sources": [{"directness": "review-level", "doi": "10.1186/s12883-026-04780-1", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Clinical and economic outcomes of therapeutic plasma exchange and intravenous immunoglobulin for treating adults with…

source_f137b71204034dc4

{"content_hash": "sha256:81fbfbc704bd719b9e8ebf952d6ebeed6231208b79bb9fd2cb613dafa19853e4", "edges": [{"from": "21652f17-8a22-4863-aa37-ec5f4e1a7b90", "to": "claim_1", "type": "contains_claim"}, {"from": "21652f17-8a22-4863-aa37-ec5f4e1a7b90", "to": "claim_2", "type": "contains_claim"}, {"from": "21652f17-8a22-4863-aa37-ec5f4e1a7b90", "to": "claim_3", "type": "contains_claim"}, {"from": "21652f17-…

source_ce339c305c3547cf

{"contradictions": ["The conclusion is that Therapeutic plasma exchange remains a bounded geroscience case: the retained clinical and adjacent evidence profile defines the scope for targeted testing, while mixed and null findings limit any unqualified anti-aging claim.", "Fuentealba 2025: Multi‐Omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single‐B…

source_4b4a538a73c842cb

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Clinical and economic outcomes of therapeutic plasma exchange and intravenous immunoglobulin for treating adults with autoimmune neurological disorders: a systematic review and meta-analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
…

source_8ebfe582295d47b8

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "21652f17-8a22-4863-aa37-ec5f4e1a7b90", "sources": [{"directness": "review-level", "doi": "10.1186/s12883-026-04780-1", "risk_of_bias": "not appraised in public sidecar", "study": "Clinical and economic outcomes of therapeutic plasma exch…

source_ce8cb485fee347c6

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}