Derivation Web

claim_745b5d500fe24225

# Adjacent Evidence Brief: Telomere Cancer Effects — full paper
## Abstract

This synthesis tests the thesis that evidence for Telomere Cancer Effects is context-dependent, separating outcome-specific signals from broader claims and identifying the evidence gaps that should bound interpretation.

Evidence-honesty note: The retained evidence has no direct interventional hard-endpoint evidence; indi…

source_722fcae18f354ef7

# Adjacent Evidence Brief: Telomere Cancer Effects — full paper
## Abstract

This synthesis tests the thesis that evidence for Telomere Cancer Effects is context-dependent, separating outcome-specific signals from broader claims and identifying the evidence gaps that should bound interpretation.

Evidence-honesty note: The retained evidence has no direct interventional hard-endpoint evidence; indi…

source_f7958856b18f4cb4

{"publication_id": "054f72de-a886-4506-a529-11d92344f009", "traces": [{"candidate_sources": [{"directness": "review-level", "doi": "10.37349/etat.2025.1002289", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Shorter telomere length as a prognostic marker for survival and recurrence in breast cancer: a systematic review and …

source_0ed70051348f432a

{"content_hash": "sha256:0b8eec7084df48cfcdfd0f940d669e121eae847e31c36324d04ef97b4789e950", "edges": [{"from": "054f72de-a886-4506-a529-11d92344f009", "to": "claim_1", "type": "contains_claim"}, {"from": "054f72de-a886-4506-a529-11d92344f009", "to": "claim_2", "type": "contains_claim"}, {"from": "054f72de-a886-4506-a529-11d92344f009", "to": "claim_3", "type": "contains_claim"}, {"from": "054f72de-…

source_c1c00a7585314aaf

{"contradictions": ["Positive study-level signals are summarized in the frailty outcome class; null signals are summarized in the immune and inflammation and mechanism outcome classes; negative signals are summarized in the dosing and pharmacokinetics outcome class; mixed or heterogeneous signals are summarized in the contextual adjacent evidence, mortality and survival, and longevity outcome clas…

source_df625103c6f94550

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Shorter telomere length as a prognostic marker for survival and recurrence in breast cancer: a systematic review and meta-analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"Telomere lengths in women treated for breast cancer show a…

source_520d7698c4874ccc

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "054f72de-a886-4506-a529-11d92344f009", "sources": [{"directness": "review-level", "doi": "10.37349/etat.2025.1002289", "risk_of_bias": "not appraised in public sidecar", "study": "Shorter telomere length as a prognostic marker for surviv…

source_2854f6668d7848e3

{"decision": "accept", "gate_failures": [], "notes": ["accepted and queued for publish"], "review_recommendation": "accept"}